MTMR6 Antikörper (AA 382-621)

Produktnummer ABIN7268765

Der Kaninchen Polyklonal anti-MTMR6 Antikörper wird verwendet zum Nachweis von MTMR6 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für MTMR6 Antikörper (AA 382-621) (ABIN7268765)

Target: MTMR6 (Myotubularin Related Protein 6 (MTMR6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTMR6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MTMR6 Antikörper

Bindungsspezifität: AA 382-621

Verwendungszweck: MTMR6 Rabbit pAb

Sequenz: RCGQLDGDPK EVSPVFTQFL ECVWHLTEQF PQAFEFSEAF LLQIHEHIHS CQFGNFLGNC QKEREELKLK EKTYSLWPFL LEDQKKYLNP LYSSESHRFT VLEPNTVSFN FKFWRNMYHQ FDRTLHPRQS VFNIIMNMNE QNKQLEKDIK DLESKIKQRK NKQTDGILTK ELLHSVHPES PNLKTSLCFK EQTLLPVNDA LRTIEGSSPA DNRYSEYAEE FSKSEPAVVS LEYGVARMTC

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 382-621 of human MTMR6 (NP_004676.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:200 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MTMR6

Target: MTMR6 (Myotubularin Related Protein 6 (MTMR6))

Andere Bezeichnung: MTMR6

Hintergrund: Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3P and phosphatidylinositol 3,5-bisphosphate (Probable. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5P2 but also to phosphatidylinositol 3-phosphate (PtdIns(3P, phosphatidylinositol 4-phosphate (PtdIns(4P, and phosphatidylinositol 5-phosphate (PtdIns(5P, phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport (By similarity. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+ T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels.,MTMR6,Signal Transduction,MTMR6

Molekulargewicht: 63kDa/71kDa

Gen-ID: 9107

UniProt: Q9Y217

Pathways: Inositol Metabolic Process