GAPVD1 Antikörper (AA 1-260)

Produktnummer ABIN7267529

Der Kaninchen Polyklonal Anti-GAPVD1-Antikörper wurde für WB und IF validiert. Er ist geeignet, GAPVD1 in Proben von Human zu detektieren.

Kurzübersicht für GAPVD1 Antikörper (AA 1-260) (ABIN7267529)

Target: GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GAPVD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-GAPVD1 Antikörper

Bindungsspezifität: AA 1-260

Verwendungszweck: GAPVD1 Rabbit pAb

Sequenz: MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS DRFRQKVQEM VESNEAKLVA

Kreuzreaktivität: Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human GAPVD1 (NP_056450.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GAPVD1

Target: GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))

Andere Bezeichnung: GAPVD1

Hintergrund: Acts both as a GTPase-activating protein (GAP and a guanine nucleotide exchange factor (GEF, and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.,GAPVD1,GAPEX5,GAPex-5,RAP6,Cancer,Signal Transduction,G protein signaling,Signal Transduction,Endocrine & Metabolism,GAPVD1

Molekulargewicht: 165kDa

Gen-ID: 26130

UniProt: Q14C86