FGL1 Antikörper

Produktnummer ABIN7267179

Dieses Anti-FGL1-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von FGL1 in WB. Geeignet für Human.

Kurzübersicht für FGL1 Antikörper (ABIN7267179)

Target: FGL1 (Fibrinogen-Like 1 (FGL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser FGL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FGL1 Antikörper

Verwendungszweck: FGL1 Rabbit mAb

Kreuzreaktivität: Human

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human FGL-1 Full length.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.09 % sodium azide,50 % glycerol, pH 7.4.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FGL1

Target: FGL1 (Fibrinogen-Like 1 (FGL1))

Andere Bezeichnung: FGL1

Hintergrund: Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. The FGL1-LAG-3 pathway maybe an important immune evasion mechanism and could contribute to current cancer immunotherapy efforts for several reasons. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner. FGL1 is highly produced by human cancer cells, and elevated FGL1 in the plasma of cancer patients is associated with a poor prognosis and resistance to anti-PD-1/B7-H1 therapy,FGL1,HFREP1,HP-041,LFIRE-1,LFIRE1,Cardiovascular,Blood,Coagulation,Serum Proteins,FGL1

Molekulargewicht: 36kDa

Gen-ID: 2267

UniProt: Q08830