FEM1A Antikörper (AA 100-300)

Produktnummer ABIN7267165

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FEM1A in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FEM1A Antikörper (AA 100-300) (ABIN7267165)

Target: FEM1A (Fem-1 Homolog A (FEM1A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FEM1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FEM1A Antikörper

Bindungsspezifität: AA 100-300

Verwendungszweck: FEM1A Rabbit pAb

Sequenz: RSLLRRGASV NRTTRTNSTP LRAACFDGHL EVVRYLVGEH QADLEVANRH GHTCLMISCY KGHREIARYL LEQGAQVNRR SAKGNTALHD CAESGSLEIL QLLLGCKARM ERDGYGMTPL LAASVTGHTN IVEYLIQEQP GQEQVAGGEA QPGLPQEDPS TSQGCAQPQG APCCSSSPEE PLNGESYESC CPTSREAAVE A

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human FEM1A (NP_061178.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FEM1A

Target: FEM1A (Fem-1 Homolog A (FEM1A))

Andere Bezeichnung: FEM1A

Hintergrund: Substrate-recognition component of a Cul2-RING (CRL2 E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity.,FEM1A,EPRAP,Cell Biology & Developmental Biology,Apoptosis,Caspases,FEM1A

Molekulargewicht: 73kDa

Gen-ID: 55527

UniProt: Q9BSK4