Doublecortin Antikörper (AA 240-360)

Produktnummer ABIN7266840

Dieses Anti-Doublecortin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Doublecortin in IF. Geeignet für Human.

Kurzübersicht für Doublecortin Antikörper (AA 240-360) (ABIN7266840)

Target: Doublecortin (DCX)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Doublecortin Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktdetails anti-Doublecortin Antikörper

Bindungsspezifität: AA 240-360

Verwendungszweck: DCX Rabbit pAb

Sequenz: HDFFGDDDVF IACGPEKFRY AQDDFSLDEN ECRVMKGNPS ATAGPKASPT PQKTSAKSPG PMRRSKSPAD SANGTSSSQL STPKSKQSPI STPTSPGSLR KHKDLYLPLS LDDSDSLGDS M

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 240-360 of human DCX (NP_835364.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Doublecortin

Target: Doublecortin (DCX)

Andere Bezeichnung: DCX

Hintergrund: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010],DBCN;DC;LISX;SCLH;XLIS;DCX,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cell Adhesion,Microtubules,Neuroscience,Cell Type Marker,Neuron marker,Growth Cone,DCX

Molekulargewicht: 40kDa

Gen-ID: 1641

UniProt: O43602