DNER Antikörper (AA 140-240)

Produktnummer ABIN7266727

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DNER in WB und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für DNER Antikörper (AA 140-240) (ABIN7266727)

Target: DNER (delta/notch-Like EGF Repeat Containing (DNER))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNER Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-DNER Antikörper

Bindungsspezifität: AA 140-240

Verwendungszweck: DNER Rabbit pAb

Sequenz: PATGWTESMA PRQLQPVPAT QEPDKILPRS QATVTLPTWQ PKTGQKVVEM KWDQVEVIPD IACGNASSNS SAGGRLVSFE VPQNTSVKIR QDATASLILL W

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human DNER (NP_620711.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:200 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu DNER

Target: DNER (delta/notch-Like EGF Repeat Containing (DNER))

Andere Bezeichnung: DNER

Hintergrund: DNER (Delta/Notch-like EGF-related receptor), also known as BET (brain-specific EGF-like transmembrane protein), is a type I transmembrane glycoprotein of the Notch/Delta family . In the mouse, DNER has been detected as 90, 120 and 150 kDa forms which are probably variably glycosylated .Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.DNER associates with protein tyrosine phosphatase zeta (PTP zeta ), which is the receptor of pleiotrophin (PTN). PTP zeta -PTN-DNER signaling has been implicated in the regulation of neuritogenesis. Expression of DNER in glioblastoma stem-like cells inhibits formation of neurospheres in vitro, while in vivo it induces differentiation and inhibits growth of xenografts, thus acting as a tumor suppressor.,DNER,UNQ26,bet,Neuroscience,Stem Cells,DNER

Molekulargewicht: 78kDa

Gen-ID: 92737

UniProt: Q8NFT8

Pathways: Skeletal Muscle Fiber Development