CHCHD2 Antikörper (AA 75-145)

Produktnummer ABIN7266448

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CHCHD2 in WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CHCHD2 Antikörper (AA 75-145) (ABIN7266448)

Target: CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHCHD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Güteklasse: KO Validated

Produktdetails anti-CHCHD2 Antikörper

Bindungsspezifität: AA 75-145

Verwendungszweck: [KO Validated] CHCHD2 Rabbit pAb

Sequenz: TLGHAITGGF SGGSNAEPAR PDITYQEPQG TQPAQQQQPC LYEIKQFLEC AQNQGDIKLC EGFNEVLKQC R

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 75-145 of human CHCHD2 (NP_057223.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CHCHD2

Target: CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))

Andere Bezeichnung: CHCHD2

Hintergrund: The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.,CHCHD2,C7orf17,MNRR1,NS2TP,PARK22,Cell Biology & Developmental Biology,CHCHD2

Molekulargewicht: 15kDa

Gen-ID: 51142

UniProt: Q9Y6H1