CCDC47 Antikörper (AA 224-483)

Produktnummer ABIN7266438

Dieses Anti-CCDC47-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CCDC47 in WB und IF. Geeignet für Human.

Kurzübersicht für CCDC47 Antikörper (AA 224-483) (ABIN7266438)

Target: CCDC47 (Coiled-Coil Domain Containing 47 (CCDC47))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCDC47 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-CCDC47 Antikörper

Bindungsspezifität: AA 224-483

Verwendungszweck: CCDC47 Rabbit pAb

Sequenz: FLKRQDLLNV LARMMRPVSD QVQIKVTMND EDMDTYVFAV GTRKALVRLQ KEMQDLSEFC SDKPKSGAKY GLPDSLAILS EMGEVTDGMM DTKMVHFLTH YADKIESVHF SDQFSGPKIM QEEGQPLKLP DTKRTLLFTF NVPGSGNTYP KDMEALLPLM NMVIYSIDKA KKFRLNREGK QKADKNRARV EENFLKLTHV QRQEAAQSRR EEKKRAEKER IMNEEDPEKQ RRLEEAALRR EQKKLEKKQM KMKQIKVKAM

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 224-483 of human CCDC47 (NP_064583.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CCDC47

Target: CCDC47 (Coiled-Coil Domain Containing 47 (CCDC47))

Andere Bezeichnung: CCDC47

Hintergrund: Component of the PAT complex, an endoplasmic reticulum (ER-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs, releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation pathway. Has an essential role in the maintenance of ER organization during embryogenesis (By similarity.,CCDC47,GK001,MSTP041,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,CCDC47

Molekulargewicht: 55kDa

Gen-ID: 57003

UniProt: Q96A33