CMKLR1 Antikörper (AA 250-350)
Kurzübersicht für CMKLR1 Antikörper (AA 250-350) (ABIN7266326)
Target
Alle CMKLR1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 250-350
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Verwendungszweck
- CMKLR1 Rabbit pAb
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Sequenz
- NRLAKTKKPF KIIVTIIITF FLCWCPYHTL NLLELHHTAM PGSVFSLGLP LATALAIANS CMNPILYVFM GQDFKKFKVA LFSRLVNALS EDTGHSSYPS H
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Kreuzreaktivität
- Human, Maus
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Produktmerkmale
- Polyclonal Antibodies
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Aufreinigung
- Affinity purification
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Immunogen
- A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CMKLR1 (NP_001135815.1).
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Isotyp
- IgG
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Applikationshinweise
- WB,1:500 - 1:2000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))
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Andere Bezeichnung
- CMKLR1
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Hintergrund
- Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i/G(o and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2, TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis PubMed:27716822. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2 and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism.,CMKLR1,CHEMERINR,ChemR23,DEZ,RVER1,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Bone,CMKLR1
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Molekulargewicht
- 42kDa
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Gen-ID
- 1240
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UniProt
- Q99788
Target
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