Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

BAZ2A Antikörper

Dieses Anti-BAZ2A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BAZ2A in WB, IF und IHC. Geeignet für Human.
Produktnummer ABIN7265937

Kurzübersicht für BAZ2A Antikörper (ABIN7265937)

Target

Alle BAZ2A Antikörper anzeigen
BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Reaktivität

Human

Wirt

  • 17
  • 1
Kaninchen

Klonalität

  • 18
Polyklonal

Konjugat

  • 8
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser BAZ2A Antikörper ist unkonjugiert

Applikation

  • 8
  • 7
  • 3
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
  • Verwendungszweck

    BAZ2A Rabbit pAb

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Polyclonal Antibodies

    Aufreinigung

    Affinity purification

    Immunogen

    Recombinant fusion protein of Human BAZ2A.

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

    Andere Bezeichnung

    BAZ2A

    Hintergrund

    Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex. The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex. Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac, leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity.,TIP5,WALp3,BAZ2A / TIP5,BAZ2A,Epigenetics & Nuclear Signaling,BAZ2A

    Gen-ID

    11176

    UniProt

    Q9UIF9
Sie sind hier:
Chat with us!