BAG4 Antikörper (AA 1-100)

Produktnummer ABIN7265852

Der Kaninchen Polyklonal Anti-BAG4-Antikörper wurde für WB und IHC validiert. Er ist geeignet, BAG4 in Proben von Human zu detektieren.

Kurzübersicht für BAG4 Antikörper (AA 1-100) (ABIN7265852)

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-BAG4 Antikörper

Bindungsspezifität: AA 1-100

Verwendungszweck: BAG4 Rabbit pAb

Sequenz: MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HPPPPLYPLR PEPPQPPISW RVRGGGPAET TWLGEGGGGD GYYPSGGAWP EPGRAGGSHQ SLNSYTNGAY

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BAG4 (NP_001191807.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:100 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu BAG4

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Andere Bezeichnung: BAG4

Hintergrund: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.,BAG4,BAG-4,SODD,Cell Biology & Developmental Biology,Apoptosis,BAG4

Molekulargewicht: 45kDa/49kDa

Gen-ID: 9530

UniProt: O95429

Pathways: Regulation of Actin Filament Polymerization