alpha Actinin 4 Antikörper (AA 570-650)

Produktnummer ABIN7265400

Dieses Anti-alpha Actinin 4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von alpha Actinin 4 in WB und IF. Geeignet für Human.

Kurzübersicht für alpha Actinin 4 Antikörper (AA 570-650) (ABIN7265400)

Target: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser alpha Actinin 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-alpha Actinin 4 Antikörper

Bindungsspezifität: AA 570-650

Verwendungszweck: α-Actinin-4 Rabbit pAb

Sequenz: HDQFKSTLPD ADREREAILA IHKEAQRIAE SNHIKLSGSN PYTTVTPQII NSKWEKVQQL VPKRDHALLE EQSKQQSNEH L

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 570-650 of human alpha-Actinin-4 (NP_004915.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu alpha Actinin 4

Target: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Andere Bezeichnung: ACTN4

Hintergrund: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.,ACTN4,ACTININ-4,FSGS,FSGS1,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Microfilaments,Extracellular Matrix,Endocrine & Metabolism,Immunology & Inflammation,T Cell Receptor Signaling Pathway,ACTN4

Molekulargewicht: 59kDa/79kDa/104kDa

Gen-ID: 81

UniProt: O43707

Pathways: Proton Transport