alpha Actinin 4 Antikörper

Produktnummer ABIN7265399

Der Kaninchen Monoklonal Anti-alpha Actinin 4-Antikörper wurde für WB, IP und IF validiert. Er ist geeignet, alpha Actinin 4 in Proben von Human zu detektieren.

Kurzübersicht für alpha Actinin 4 Antikörper (ABIN7265399)

Target: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser alpha Actinin 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Produktdetails anti-alpha Actinin 4 Antikörper

Verwendungszweck: α-Actinin-4 Rabbit mAb

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human alpha-Actinin-4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu alpha Actinin 4

Target: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Andere Bezeichnung: ACTN4

Hintergrund: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008],ACTININ-4, FSGS, FSGS1,Cancer,Cell Adhesion,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Microfilaments,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,Extracellular Matrix,Immunology & Inflammation,Invasion and Metastasis,RNA Binding,Signal Transduction,T Cell Receptor Signaling Pathway,ACTN4

Molekulargewicht: 105kDa

Gen-ID: 81

UniProt: O43707

Pathways: Proton Transport