Tetraspanin 3 Antikörper (Extracellular, Loop 2)

Produktnummer ABIN7886695

Der Kaninchen Polyklonal anti-Tetraspanin 3 Antikörper wird verwendet zum Nachweis von Tetraspanin 3 in Proben von Human. Er wurde validiert für WB, IHC, FACS und LCI.

Kurzübersicht für Tetraspanin 3 Antikörper (Extracellular, Loop 2) (ABIN7886695)

Target: Tetraspanin 3 (TSPAN3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tetraspanin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Produktdetails anti-Tetraspanin 3 Antikörper

Bindungsspezifität: AA 155-169, Extracellular, Loop 2

Verwendungszweck: A Rabbit Polyclonal antibody to Tetraspanin-3 (extracellular)

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,rat - identical

Produktmerkmale: Extracellular, 2nd loop

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DWENTDWFKETKNQS, corresponding to amino acid residues 155 - 169 of human Tetraspanin-3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200-1:400

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237377)

Blocking Peptide: (ABIN7237377)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Tetraspanin 3

Target: Tetraspanin 3 (TSPAN3)

Andere Bezeichnung: TSPAN3

Hintergrund:

Synonyms: TSPAN3, Transmembrane 4 Superfamily Member 8, TM4SF8

Description: Tetraspanin-3, encoded by TSPAN3 gene is a membrane-spanning glycoprotein that has a role in cell migration, proliferation, and interactions between cells and extracellular matrix.As suggested by the family name, TSPANs are categorized by the presence of four trans-membrane domains, of which two are extracellular. The intracellular part includes the C and N terminal domains that can facilitate protein-protein interactions, as well as guide intracellular trafficking. TSPANs have multiple roles In the immune and vascular systems, and they act as organizers of functional microdomains and multi-subunit receptor complexes 1.Tspan3 is highly expressed in the brain and elevated in brains of Alzheimers disease (AD) patients. It was shown to interact with ADAM10, which is a marker for Alzheimer's disease 2. It was also shown to be expressed by dendritic cells (DCs) which suggests that it may be involved in the function of DCs in association with T cell stimulation 3.Its functional diversity and importance for the development and onset of various diseases makes Tetraspanin 3 an appealing research target.

Gen-ID: 10099

NCBI Accession: NM_005724

UniProt: O60637