Tetraspanin 3 Antikörper (Extracellular)

Produktnummer ABIN7237881

Der Kaninchen Polyklonal Anti-Tetraspanin 3-Antikörper wurde für WB, IHC, FACS und LCI validiert. Er ist geeignet, Tetraspanin 3 in Proben von Human zu detektieren.

Kurzübersicht für Tetraspanin 3 Antikörper (Extracellular) (ABIN7237881)

Target: Tetraspanin 3 (TSPAN3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tetraspanin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Produktdetails anti-Tetraspanin 3 Antikörper

Bindungsspezifität: AA 155-169, Extracellular

Verwendungszweck: A Rabbit Polyclonal antibody to Tetraspanin-3 (extracellular)

Spezifität: Extracellular, 2nd loop.

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,rat - identical

Produktmerkmale: Extracellular, 2nd loop

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)DWENTDWFKETKNQS, corresponding to amino acid residues 155 - 169 of human Tetraspanin-3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

Application Dilutions Western blot wb: 1:200-1:400

Kommentare:

Negative Control: (ABIN7237377)

Blocking Peptide: (ABIN7237377)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu Tetraspanin 3

Target: Tetraspanin 3 (TSPAN3)

Andere Bezeichnung: TSPAN3

Hintergrund: TSPAN3, Transmembrane 4 Superfamily Member 8, TM4SF8,Tetraspanin-3, encoded by TSPAN3 gene is a membrane-spanning glycoprotein that has a role in cell migration, proliferation, and interactions between cells and extracellular matrix.As suggested by the family name, TSPANs are categorized by the presence of four trans-membrane domains, of which two are extracellular. The intracellular part includes the C and N terminal domains that can facilitate protein-protein interactions, as well as guide intracellular trafficking. TSPANs have multiple roles In the immune and vascular systems, and they act as organizers of functional microdomains and multi-subunit receptor complexes 1.Tspan3 is highly expressed in the brain and elevated in brains of Alzheimers disease (AD) patients. It was shown to interact with ADAM10, which is a marker for Alzheimer's disease 2. It was also shown to be expressed by dendritic cells (DCs) which suggests that it may be involved in the function of DCs in association with T cell stimulation 3.Its functional diversity and importance for the development and onset of various diseases makes Tetraspanin 3 an appealing research target.

Alternative names: TSPAN3, Transmembrane 4 Superfamily Member 8, TM4SF8

Gen-ID: 10099

NCBI Accession: NM_005724

UniProt: O60637