SSTR3 Antikörper (Intracellular)

Produktnummer ABIN7887138

Der Kaninchen Polyklonal anti-SSTR3 Antikörper wird verwendet zum Nachweis von SSTR3 in Proben von Ratte. Er wurde validiert für WB, IHC und IF.

Kurzübersicht für SSTR3 Antikörper (Intracellular) (ABIN7887138)

Target: SSTR3 (Somatostatin Receptor 3 (SSTR3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSTR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-SSTR3 Antikörper

Bindungsspezifität: AA 233-246, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 3

Kreuzreaktivität: Maus, Ratte

Homologie: Mouse - identical, human - 11,14 amino acid residues identical

Produktmerkmale: Intracellular, between transmembrane domains 5 and 6

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: KVRSTTRRVRAPSC, corresponding to amino acid residues 233-246 of rat SSTR3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237243)

Blocking Peptide: (ABIN7237243)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu SSTR3

Target: SSTR3 (Somatostatin Receptor 3 (SSTR3))

Andere Bezeichnung: SSTR3

Hintergrund:

Synonyms: SSTR3, SS3R, Smstr3

Description: Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as practically every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28 that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. SST induces in target cells a variety of physiological functions that include nueromodulation, cell secretion, cell proliferation and smooth muscle contractility.SST acts on its multiple cell targets via a family of six receptors that are originated form five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell response via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation.SSTRs are expressed widely in both the brain and peripheral tissues but with receptor subtype variations between the different cell types. Thus, SSTR3 expression in the brain is primarily concentrated in the cerebellum with lesser expression in peripheral organs such as the spleen, the liver and the pituitary.Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain.

Gen-ID: 171044

NCBI Accession: NM_001051

UniProt: P30936