SSTR3 Antikörper (Intracellular)

Produktnummer ABIN7237867

Der Kaninchen Polyklonal Anti-SSTR3-Antikörper wurde für WB, IHC und IF validiert. Er ist geeignet, SSTR3 in Proben von Ratte zu detektieren.

Kurzübersicht für SSTR3 Antikörper (Intracellular) (ABIN7237867)

Target: SSTR3 (Somatostatin Receptor 3 (SSTR3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSTR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-SSTR3 Antikörper

Bindungsspezifität: AA 233-246, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 3

Spezifität: Intracellular, between transmembrane domains 5 and 6

Kreuzreaktivität: Maus, Ratte

Homologie: Mouse - identical, human - 11,14 amino acid residues identical

Produktmerkmale: Intracellular, between transmembrane domains 5 and 6

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: KVRSTTRRVRAPSC, corresponding to amino acid residues 233-246 of rat SSTR3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Kommentare:

Negative Control: (ABIN7237243)

Blocking Peptide: (ABIN7237243)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu SSTR3

Target: SSTR3 (Somatostatin Receptor 3 (SSTR3))

Andere Bezeichnung: SSTR3

Hintergrund: SSTR3, SS3R, Smstr3,Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as practically every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28 that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. SST induces in target cells a variety of physiological functions that include nueromodulation, cell secretion, cell proliferation and smooth muscle contractility.SST acts on its multiple cell targets via a family of six receptors that are originated form five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell response via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation.SSTRs are expressed widely in both the brain and peripheral tissues but with receptor subtype variations between the different cell types. Thus, SSTR3 expression in the brain is primarily concentrated in the cerebellum with lesser expression in peripheral organs such as the spleen, the liver and the pituitary.Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain.

Alternative names: Somatostatin Receptor Type 3, SSTR3, SS3R, Smstr3,

Gen-ID: 171044

NCBI Accession: NM_001051

UniProt: P30936