NPX1 Antikörper (Secreted)

Produktnummer ABIN7237737

Dieser Anti-NPX1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von NPX1 in WB und IHC. Geeignet für Maus.

Kurzübersicht für NPX1 Antikörper (Secreted) (ABIN7237737)

Target: NPX1 (Neuronal Pentraxin 1 (NPX1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-NPX1 Antikörper

Bindungsspezifität: AA 197-211, Secreted

Verwendungszweck: A Rabbit Polyclonal antibody to Neuronal Pentraxin 1 (NPTX1)

Spezifität: Secreted

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat - identical, Human - 13 out of 15 amino acid residues identical

Produktmerkmale: Secreted

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)ERAKIESALTSLHQR, corresponding to amino acid residues 197 - 211 of mouse NPTX1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

Application Dilutions Western blot wb: 1:400

Kommentare:

Negative Control: (ABIN7236078)

Blocking Peptide: (ABIN7236078)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu NPX1

Target: NPX1 (Neuronal Pentraxin 1 (NPX1))

Andere Bezeichnung: NPTX1

Hintergrund: Neuronal Pentraxin-1, NP1,Neuronal Pentraxin 1 (NP1 or NPTX1) is a 47-50 kDa secreted glycoprotein that is expressed in the central nervous system and involved in excitatory synaptic remodeling1. The pentraxin superfamily members are made from monomers arranged in pentameric structures with a discoid shape. The family members are characterized by a 205 amino acids long conserved sequence located at C-terminal called the pentraxin domain with a shorter inner conserved sequence called the pentraxin signature 2.NP1 is preferentially expressed in the brain and is involved in glutamate receptor internalization. It is secreted pre-synaptically and implicated in excitatory synaptic and mitochondrial deficits. In addition, NP1 may represent a potential synapse-derived plasma biomarker that is able to identify alterations in excitatory synapses and early-onset Alzheimer's disease3.

Alternative names: Neuronal Pentraxin-1, NP1

Gen-ID: 18164

NCBI Accession: NM_018713

UniProt: Q62443

Pathways: Carbohydrate Homeostasis, Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, SARS-CoV-2 Protein Interaktom