LRRC4 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7886680

Der Kaninchen Polyklonal anti-LRRC4 Antikörper wird verwendet zum Nachweis von LRRC4 in Proben von Maus. Er wurde validiert für WB, IHC, FACS und LCI.

Kurzübersicht für LRRC4 Antikörper (Extracellular, N-Term) (ABIN7886680)

Target: LRRC4 (Leucine Rich Repeat Containing 4 (LRRC4))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Produktdetails anti-LRRC4 Antikörper

Bindungsspezifität: AA 507-520, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal antibody to NGL-2/LRRC4 (extracellular)

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat - identical,Human 13 out of 14 amino acid residues identical

Produktmerkmale: Extracellular, N-terminus

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)STDTTDKMQTSLDE, corresponding to amino acid residues 507 - 520 of mouse LRRC4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235857)

Blocking Peptide: (ABIN7235857)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu LRRC4

Target: LRRC4 (Leucine Rich Repeat Containing 4 (LRRC4))

Andere Bezeichnung: LRRC4 

Hintergrund:

Synonyms: Netrin-G2 Ligand, Brain Tumor-Associated Protein BAG, Leucine-Rich Repeat-Containing Protein 4

Description: The leucine-rich repeat (LRR) superfamily is a diverse protein family that consist of leucine-rich domains (LRR domains). The LRR domain is known to regulate protein-protein interaction or cell adhesion. Large portion of LRR proteins mediate the differentiation and development of nervous tissues1. One member of the LRR superfamily is leucine rich repeat containing protein 4 (LRRC4), also known as netrin-G ligand-2 (NGL-2), and serves as a receptor for netrin-G2 (NTNG2). In addition to the LRR domain LRRC4 consist of immunoglobulin (Ig) domain in the extracellular region, a transmembrane domain, and a cytoplasmic region that terminates in a protein-protein interaction domain (PDZ)-binding motif. LRRC4 regulates the formation of excitatory synapses and promotes axon differentiation2.Functionally, deletion of LRRC4 in mice was found to suppress excitatory synapse development and synaptic transmission. In addition, LRRC4 gene has been identified as tumor suppressor3. In human it has been implicated in autism spectrum disorder (ASD), schizophrenia, and intellectual disability. Moreover, netrin-G2, the presynaptic ligand of LRRC4, is linked to schizophrenia and bipolar disorder4-5.

Gen-ID: 192198

NCBI Accession: NM_022143

UniProt: Q99PH1

Pathways: Synaptic Membrane