Bassoon Antikörper (AA 786-1041)

Produktnummer ABIN7233033

Dieses Anti-Bassoon-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Bassoon in IHC, WB und IF. Geeignet für Human.

Kurzübersicht für Bassoon Antikörper (AA 786-1041) (ABIN7233033)

Target: Bassoon (BSN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Bassoon Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-Bassoon Antikörper

Bindungsspezifität: AA 786-1041

Verwendungszweck: Anti-Bassoon Rabbit Polyclonal Antibody

Spezifität: This antibody recognizes human, mouse, and rat Bassoon. Multiple isoforms are detected.

Kreuzreaktivität: Human, Maus, Ratte

Immunogen: Fusion protein corresponding to aa786-1041 (N-terminal) of human Bassoon (accession no. NM_003458.3).

Anwendungsinformationen

Applikationshinweise: Immunoblotting: use at 1 μg/mL.
Immunohistochemistry: use at 1-10 μg/mL.
Immunofluorescence: use at 1-10 μg/mL.
Positive control: Rat brain tissue lysate
These are recommended concentrations,
Enduser should determine optimal concentrations for their applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: This antibody is stable for at least one (1) year at -20°C.

Details zu Bassoon

Target: Bassoon (BSN)

Andere Bezeichnung: BSN

Hintergrund: Protein bassoon,Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to rUniProtKB:O88778, PubMed:12812759, PubMed:19380881}.,Bassoon, a 420 kDa protein, is localized at presynaptic nerve terminals and appears to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The C-terminal regions of the polyglutamine domains are of interest since abnormal amplification of this region in some human proteins, such as Huntingtin, can cause late-onset neuro- degeneration.,Cytoplasm, Cell junction, synapse, presynaptic active zone, Cytoplasm, cytoskeleton, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane,Zinc finger protein 231

UniProt: Q9UPA5