Becn2 Antikörper

Produktnummer ABIN7232892

Produktdetails

Target: Becn2

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (fixed cells) (IF/ICC)

Verwendungszweck: Anti-Beclin2 Rabbit Polyclonal Antibody

Spezifität: This antibody recognizes human and rat Beclin 2.

Kreuzreaktivität: Human, Ratte

Immunogen: Synthetic peptide corresponding to mid-protein amino acids of human Beclin 2.

Anwendungsinformationen

Applikationshinweise: Immunoblotting: use at 1-2 μg/mL. A band of ~50 kDa is detected.Detection of Beclin 2 in 20 μg rat liver lysate.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: This antibody is stable for at least one (1) year at -20°C.

Antigendetails

Target: Becn2

Synonyme: Beclin-2 antikoerper, Gm104 antikoerper, beclin 2 antikoerper, Becn2 antikoerper

Hintergrund: Beclin-2,Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. {PubMed:23954414}.,Autophagy is a catabolic process that results in the degradation of bulk cytoplasmic contents within autophagosomes and lysosomes. Beclin 2 is an Atg6/Beclin family member that functions in two distinct lysosomal degradation pathways, autophagy and the downregulation of certain seven- transmembrane-spanning GPCRs. Its role in GPCR lysosomal degradation does not involve Beclin 1 or other Beclin 1/2-interacting proteins such as ATG14 and VPS34 that function in autophagy. Its role in lysosomal degradation also appears to differ from other autophagy- independent functions previously described for yeast Atg6/Vps30 or mammalian Beclin 1, such as vacuolar protein sorting and EGFR degradation.,Cytoplasm,Beclin-1 autophagy-related pseudogene 1, Beclin-1-like protein 1

UniProt: A8MW95