TNKS2 Antikörper (AA 950-1030)

Produktnummer ABIN7231854

Dieser Anti-TNKS2 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von TNKS2 in WB und ELISA. Geeignet für Human und Maus.

Kurzübersicht für TNKS2 Antikörper (AA 950-1030) (ABIN7231854)

Target: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNKS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-TNKS2 Antikörper

Bindungsspezifität: AA 950-1030

Verwendungszweck: TNKS2 Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of TNKS2 protein

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human TNKS2 protein at AA range: 950-1030

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu TNKS2

Target: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Andere Bezeichnung: TNKS2

Hintergrund: Rabbit Anti-TNKS2 Polyclonal Antibody,Tankyrase-2, TANK2, ADP-ribosyltransferase diphtheria toxin-like 6, ARTD6, Poly [ADP-ribose] polymerase 5B, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein,TNKS2 (Tankyrase 2) is a Protein Coding gene. Among its related pathways are phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex and HIV Life Cycle. GO annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is TNKS. Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.,TNKS2

Molekulargewicht: observerd band 128kDa

Gen-ID: 80351

UniProt: Q9H2K2