SESN1 Antikörper (AA 240-320)

Produktnummer ABIN7221122

Dieser Anti-SESN1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von SESN1 in WB, ELISA und IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für SESN1 Antikörper (AA 240-320) (ABIN7221122)

Target: SESN1 (Sestrin 1 (SESN1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SESN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SESN1 Antikörper

Bindungsspezifität: AA 240-320

Verwendungszweck: PA26 Polyclonal Antibody

Spezifität: PA26 Polyclonal Antibody detects endogenous levels of PA26 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human PA26 at AA range: 240-320

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu SESN1

Target: SESN1 (Sestrin 1 (SESN1))

Andere Bezeichnung: PA26

Hintergrund: Rabbit Anti-PA26 Polyclonal Antibody,SESN1, PA26, SEST1, Sestrin-1, p53-regulated protein PA26,SESN1 encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The sestrin 1 mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.,Sestrin-1

Molekulargewicht: observerd band 57kDa

Gen-ID: 27244

UniProt: Q9Y6P5