RNF111 Antikörper (AA 870-950)

Produktnummer ABIN7223318

Der Kaninchen Polyklonal anti-RNF111 Antikörper wird verwendet zum Nachweis von RNF111 in Proben von Human und Maus. Er wurde validiert für WB und ELISA.

Kurzübersicht für RNF111 Antikörper (AA 870-950) (ABIN7223318)

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF111 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RNF111 Antikörper

Bindungsspezifität: AA 870-950

Verwendungszweck: Arkadia Polyclonal Antibody

Spezifität: Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human Arkadia at AA range: 870-950

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu RNF111

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Andere Bezeichnung: Arkadia

Hintergrund: Rabbit Anti-Arkadia Polyclonal Antibody,RNF111, E3 ubiquitin-protein ligase Arkadia, RING finger protein 111,The protein encoded by RNF111 (ring finger protein 111) is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF)-beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of RNF111 results in multiple transcript variants encoding distinct isoforms.,E3 ubiquitin-protein ligase Arkadia

Gen-ID: 54778

UniProt: Q6ZNA4