RIN1 Antikörper (AA 630-710)

Produktnummer ABIN7226044

Der Kaninchen Polyklonal anti-RIN1 Antikörper (ABIN7226044) detektiert spezifisch RIN1 in ELISA, WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für RIN1 Antikörper (AA 630-710) (ABIN7226044)

Target: RIN1 (Ras and Rab Interactor 1 (RIN1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIN1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-RIN1 Antikörper

Bindungsspezifität: AA 630-710

Verwendungszweck: Rabbit Anti-RIN1 Polyclonal Antibody

Spezifität: RIN1 Polyclonal Antibody detects endogenous levels of RIN1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human RIN1 at AA range: 630-710

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu RIN1

Target: RIN1 (Ras and Rab Interactor 1 (RIN1))

Andere Bezeichnung: RIN1

Hintergrund: RIN1, Ras and Rab interactor 1, Ras inhibitor JC99, Ras interaction/interference protein 1Ras is a membrane-associated small G protein that is indirectly coupled to receptor and nonreceptor tyrosine kinases. Ras activation is regulated by the levels of bound GTP and GDP. Several effectors of Ras have been identified, including Raf1, PI 3-kinase and RIN1. RIN1 (Ras interaction/interference) was identified as a Ras-interacting protein in yeast, and it has been shown to bind to the human H-Ras. This RIN1-Ras interaction is enhanced when Ras is bound to GTP. Unlike Raf1, RIN1 is localized primarily to the plasma membrane. RIN1 contains an SH2 domain and an amino-terminal region similar to consensus SH3 domains. RIN1 binds c-Abl and, like Raf1, interacts with 14-3-3 proteins.

Molekulargewicht: 84kD

Gen-ID: 9610

UniProt: Q13671