PLOD2 Antikörper (AA 600-680)

Produktnummer ABIN7230696

Der Kaninchen Polyklonal anti-PLOD2 Antikörper (ABIN7230696) detektiert spezifisch PLOD2 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für PLOD2 Antikörper (AA 600-680) (ABIN7230696)

Target: PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLOD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PLOD2 Antikörper

Bindungsspezifität: AA 600-680

Verwendungszweck: Rabbit Anti-PLOD2 Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of PLOD2 protein

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PLOD2 protein at AA range: 600-680

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu PLOD2

Target: PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))

Andere Bezeichnung: PLOD2

Hintergrund: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, Lysyl hydroxylase 2, LH2The protein encoded by PLOD2 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of PLOD2 are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 81kD

Gen-ID: 5352

UniProt: O00469

Pathways: SARS-CoV-2 Protein Interaktom