Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) (AA 170-250) Antikörper

Produktnummer ABIN7230470

Der Kaninchen Polyklonal anti-Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 Antikörper (ABIN7230470) detektiert spezifisch Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) (AA 170-250) Antikörper (ABIN7230470)

Target: Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails

Bindungsspezifität: AA 170-250

Verwendungszweck: Rabbit Anti-PABP2 Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of PABP2 protein

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PABP2 protein at AA range: 170-250

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Antigendetails

Target: Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2)

Andere Bezeichnung: PABP2

Hintergrund: Polyadenylate-binding protein 2, PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1PABPN1 (Poly(A) Binding Protein Nuclear 1) encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. PABPN1 contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

Molekulargewicht: 33kD

Gen-ID: 8106

UniProt: Q86U42