Phospholamban Antikörper (pSer16)

Produktnummer ABIN7223212

Der Kaninchen Polyklonal Anti-Phospholamban Antikörper wurde für ELISA und IF validiert. Er ist geeignet, Phospholamban in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für Phospholamban Antikörper (pSer16) (ABIN7223212)

Target: Phospholamban (PLN)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Phospholamban Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-Phospholamban Antikörper

Bindungsspezifität: pSer16

Verwendungszweck: PLB (phospho Ser16/T17) Polyclonal Antibody

Spezifität: Phospho-PLB (S16/T17) Polyclonal Antibody detects endogenous levels of PLB protein only when phosphorylated at S16/T17.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human PLB Phospho-Ser16/T17

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu Phospholamban

Target: Phospholamban (PLN)

Andere Bezeichnung: PLB

Hintergrund: Rabbit Anti-PLB (phospho Ser16/T17) Polyclonal Antibody,PLN, PLB, Cardiac phospholamban, PLB,The protein encoded by PLN (phospholamban)is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in PLN are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.,Cardiac phospholamban

Gen-ID: 5350

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity