PDZ-RhoGEF (AA 170-250) Antikörper

Produktnummer ABIN7216492

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PDZ-RhoGEF in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für PDZ-RhoGEF (AA 170-250) Antikörper (ABIN7216492)

Target: PDZ-RhoGEF

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails

Bindungsspezifität: AA 170-250

Verwendungszweck: Rabbit Anti-PDZ-RhoGEF Polyclonal Antibody

Spezifität: PDZ-RhoGEF Polyclonal Antibody detects endogenous levels of PDZ-RhoGEF protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human PDZ-RhoGEF at AA range: 170-250

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Antigendetails

Target: PDZ-RhoGEF

Hintergrund: ARHGEF11, KIAA0380, Rho guanine nucleotide exchange factor 11, PDZ-RhoGEFPeriphilin 1 encoded by PPHLN1 is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. Periphilin 1 interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of periphilin 1 suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gen-ID: 9826

UniProt: O15085