NCOR2 Antikörper (AA 480-560)

Produktnummer ABIN7226048

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NCOR2 in WB, ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für NCOR2 Antikörper (AA 480-560) (ABIN7226048)

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCOR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-NCOR2 Antikörper

Bindungsspezifität: AA 480-560

Verwendungszweck: Rabbit Anti-SMRTe Polyclonal Antibody

Spezifität: SMRTe Polyclonal Antibody detects endogenous levels of SMRTe protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human SMRTe at AA range: 480-560

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Andere Bezeichnung: SMRTe

Hintergrund: NCOR2, CTG26, Nuclear receptor corepressor 2, N-CoR2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, SMRT, T3 receptor-associating factor, TRAC, Thyroid-, retinoic-acid-receptor-associatedNCOR2 (nuclear receptor corepressor 2) encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of NCOR2 is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 270kD

Gen-ID: 9612

UniProt: Q9Y618

Pathways: Notch Signalweg, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha