MC1 Receptor Antikörper (AA 240-320)

Produktnummer ABIN7222388

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MC1 Receptor in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für MC1 Receptor Antikörper (AA 240-320) (ABIN7222388)

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MC1 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MC1 Receptor Antikörper

Bindungsspezifität: AA 240-320

Verwendungszweck: Rabbit Anti-MC1-R Polyclonal Antibody

Spezifität: MC1-R Polyclonal Antibody detects endogenous levels of MC1-R protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human MC1-R at AA range: 240-320

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Andere Bezeichnung: MC1-R

Hintergrund: MC1R, MSHR, Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-RThis intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that MC1R(MSH) is an important component in determining normal human pigment variation.

Molekulargewicht: 35kD

Gen-ID: 4157

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour