LRRK1 Antikörper (AA 330-410)

Produktnummer ABIN7225092

Der Kaninchen Polyklonal anti-LRRK1 Antikörper (ABIN7225092) detektiert spezifisch LRRK1 in ELISA, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für LRRK1 Antikörper (AA 330-410) (ABIN7225092)

Target: LRRK1 (Leucine-Rich Repeat Kinase 1 (LRRK1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRK1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-LRRK1 Antikörper

Bindungsspezifität: AA 330-410

Verwendungszweck: Rabbit Anti-LRRK1 Polyclonal Antibody

Spezifität: LRRK1 Polyclonal Antibody detects endogenous levels of LRRK1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human LRRK1 at AA range: 330-410

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:5000,Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu LRRK1

Target: LRRK1 (Leucine-Rich Repeat Kinase 1 (LRRK1))

Andere Bezeichnung: LRRK1

Hintergrund: LRRK1, KIAA1790, Leucine-rich repeat serine/threonine-protein kinase 1The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. LRRK1 (leucine-rich repeat serine/threonine-protein kinase 1), also known as RIPK6, Roco1 or KIAA1790, is a 2038 amino acid cytoplasmic protein that contains one protein kinase domain, four ANK repeats and 11 leucine-rich repeats and belongs to the Ser/Thr protein kinase family. Using magnesium as a cofactor, LRRK1 catalyzes the ATP-dependent phosphorylation of target proteins. The gene encoding LRRK1, which is expressed as four alternatively spliced isoforms, is thought to be involved in the pathogenesis of Parkinson's disease.

Gen-ID: 79705

UniProt: Q38SD2