KCNQ2/3/4/5 (pThr217), (pThr223), (pThr246), (pThr251) Antikörper

Produktnummer ABIN7222018

Der Kaninchen Polyklonal Anti-not_set Antikörper wurde für ELISA und IHC (p) validiert. Er ist geeignet, not_set in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für KCNQ2/3/4/5 (pThr217), (pThr223), (pThr246), (pThr251) Antikörper (ABIN7222018)

Target: KCNQ2/3/4/5

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails

Bindungsspezifität: pThr217, pThr223, pThr246, pThr251

Verwendungszweck: KCNQ2/3/4/5 (phospho Thr217/246/223/251) Polyclonal Antibody

Spezifität: Phospho-KCNQ2/3/4/5 (T217/246/223/251) Polyclonal Antibody detects endogenous levels of KCNQ2/3/4/5 protein only when phosphorylated at T217/246/223/251.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human KCNQ2/3/4/5 Phospho-Thr217/246/223/251

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Antigendetails

Target: KCNQ2/3/4/5

Hintergrund: Rabbit Anti-KCNQ2/3/4/5 (phospho Thr217/246/223/251) Polyclonal Antibody,KCNQ2, Potassium voltage-gated channel subfamily KQT member 2, KQT-like 2, Neuroblastoma-specific potassium channel subunit alpha KvLQT2, Voltage-gated potassium channel subunit Kv7.2, KCNQ3, Potassium voltage-gated channel subfamily KQT me,The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.,Potassium voltage-gated channel subfamily KQT member 2

Gen-ID: 3785, 3786, 9132