GRM2 Antikörper (AA 210-290)

Produktnummer ABIN7221364

Der Kaninchen Polyklonal Anti-GRM2 Antikörper wurde für ELISA, IF und IHC (p) validiert. Er ist geeignet, GRM2 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für GRM2 Antikörper (AA 210-290) (ABIN7221364)

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRM2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GRM2 Antikörper

Bindungsspezifität: AA 210-290

Verwendungszweck: mGluR2 Polyclonal Antibody

Spezifität: MGluR2 Polyclonal Antibody detects endogenous levels of mGluR2 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human mGluR2 at AA range: 210-290

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu GRM2

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Andere Bezeichnung: mGluR2

Hintergrund: Rabbit Anti-mGluR2 Polyclonal Antibody,GRM2, GPRC1B, MGLUR2, Metabotropic glutamate receptor 2, mGluR2,L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for GRM2.,Metabotropic glutamate receptor 2

Gen-ID: 2912

UniProt: Q14416

Pathways: cAMP Metabolic Process, Dicarboxylic Acid Transport