Gab 2/4 (AA 40-120) Antikörper

Produktnummer ABIN7219526

Der Kaninchen Polyklonal anti-Gab 2/4 Antikörper (ABIN7219526) detektiert spezifisch Gab 2/4 in ELISA, IHC, WB und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Gab 2/4 (AA 40-120) Antikörper (ABIN7219526)

Target: Gab 2/4

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Produktdetails

Bindungsspezifität: AA 40-120

Verwendungszweck: Rabbit Anti-Gab 2/4 Polyclonal Antibody

Spezifität: Gab 2/4 Polyclonal Antibody detects endogenous levels of Gab 2/4 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human Gab 2/4 at AA range: 40-120

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Antigendetails

Target: Gab 2/4

Hintergrund: GAB4, GRB2-associated-binding protein 4, GRB2-associated binder 2-like, GAB2-like, GRB2-associated binder 4, GRB2-associated-binding protein 2-like, Growth factor receptor bound protein 2-associated protein 4, GAB2, KIAA0571, GRB2-associateThis gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]ADRB2 (Adrenoceptor Beta 2) is a Protein Coding gene. Diseases associated with ADRB2 include obesity and asthma. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and enzyme binding. An important paralog of this gene is TAAR9. eta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. he adrenergic beta2 receptor (beta2-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta3. They are located primarily in the CNS, heart, kidney and muscle.

Molekulargewicht: 62kD

Gen-ID: 128954

UniProt: Q2WGN9, Q9UQC2