ERLIN1/2 Antikörper (AA 31-80)

Produktnummer ABIN7226896

Der Kaninchen Polyklonal anti-ERLIN1/2 Antikörper wird verwendet zum Nachweis von ERLIN1/2 in Proben von Human, Maus und Ratte. Er wurde validiert für ELISA und WB.

Kurzübersicht für ERLIN1/2 Antikörper (AA 31-80) (ABIN7226896)

Target: ERLIN1/2

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERLIN1/2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-ERLIN1/2 Antikörper

Bindungsspezifität: AA 31-80

Verwendungszweck: Rabbit Anti-ERLIN1/2 Polyclonal Antibody

Spezifität: ERLIN1/2 Polyclonal Antibody detects endogenous levels of ERLIN1/2.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from ERLIN1/2 at AA range: 31-80

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu ERLIN1/2

Target: ERLIN1/2

Hintergrund: Erlin-1 and erlin-2 (SPFH1 and SPFH2) are SPFH domain-containing proteins that belong to the prohibitin family. The N-termal domain of erlin proteins contains ER-targeting sequences responsible for their translocation to the endoplasmic reticulum (ER). In the ER, erlin-1 and erlin-2 specifically associate with the detergent resistant lipid raft microdomain of the membrane. Erlin-1 may be involved in dentritic cell activation and erlin-2 has been shown to regulate the ER-associated degradation (ERAD) pathway by interacting with endogenous substrates and resulting in their polyubiquitination and degradation.

Molekulargewicht: 40kD,42kD

UniProt: O75477, O94905