DOK3 Antikörper (AA 70-150)

Produktnummer ABIN7214606

Der Kaninchen Polyklonal Anti-DOK3 Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, DOK3 in Proben von Human und Maus zu detektieren.

Kurzübersicht für DOK3 Antikörper (AA 70-150) (ABIN7214606)

Target: DOK3 (Docking Protein 3 (DOK3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DOK3 Antikörper

Bindungsspezifität: AA 70-150

Verwendungszweck: Dok-3 Polyclonal Antibody

Spezifität: Dok-3 Polyclonal Antibody detects endogenous levels of Dok-3 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Dok-3 at AA range: 70-150

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:20000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu DOK3

Target: DOK3 (Docking Protein 3 (DOK3))

Andere Bezeichnung: Dok-3

Hintergrund: Rabbit Anti-Dok-3 Polyclonal Antibody,DOK3, Docking protein 3, Downstream of tyrosine kinase 3,Dok-1, Dok-2 and Dok-3 are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl. Dok-3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B cells and macrophages. Immunoreceptor-mediated cellular activation induces tyrosine phosphorylation of Dok-3. Upon phosphorylation, Dok-3 binds to 5' inositol phosphatase SHIP and the protein tyrosine kinase Csk. Dok-3 may play a significant role in the negative regulation of immunoreceptor signaling in hemopoietic cells.,Docking protein 3

Molekulargewicht: observerd band 58kDa

Gen-ID: 79930

UniProt: Q7L591