RPA14 Antikörper (AA 30-80)

Produktnummer ABIN7231134

Der Kaninchen Polyklonal anti-RPA14 Antikörper (ABIN7231134) detektiert spezifisch RPA14 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für RPA14 Antikörper (AA 30-80) (ABIN7231134)

Target: RPA14 (DNA-directed RNA polymerase I subunit RPA14 (RPA14))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPA14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-RPA14 Antikörper

Bindungsspezifität: AA 30-80

Verwendungszweck: Rabbit Anti-RPA14 Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of RPA14

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human RPA14 protein at AA range: 30-80

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu RPA14

Target: RPA14 (DNA-directed RNA polymerase I subunit RPA14 (RPA14))

Andere Bezeichnung: RPA14

Hintergrund: Replication protein A 14 kDa subunit, RP-A p14, Replication factor A protein 3, RF-A protein 3As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed: 9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. RPA3 (Replication Protein A3) is a Protein Coding gene. Diseases associated with RPA3 include Epidemic Typhus and Ovary Serous Adenocarcinoma. Among its related pathways are Mismatch repair and DNA Double-Strand Break Repair.

Molekulargewicht: 14kD

Gen-ID: 6119

UniProt: P35244