Desmoglein 1 Antikörper (AA 30-90)

Produktnummer ABIN7228306

Der Kaninchen Polyklonal anti-Desmoglein 1 Antikörper (ABIN7228306) detektiert spezifisch Desmoglein 1 in WB, ELISA und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Desmoglein 1 Antikörper (AA 30-90) (ABIN7228306)

Target: Desmoglein 1 (DSG1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Desmoglein 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Desmoglein 1 Antikörper

Bindungsspezifität: AA 30-90

Verwendungszweck: Dsg1 Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of Dsg1

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human Dsg1 protein at AA range: 30-90

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:500-1:200), ELISA (1:10000-1:20000).

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu Desmoglein 1

Target: Desmoglein 1 (DSG1)

Andere Bezeichnung: Dsg1

Hintergrund: Rabbit Anti-Dsg1 Polyclonal Antibody,Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen,DSG1 encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. DSG1 is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of DSG1 has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.,Dsg1

Molekulargewicht: observerd band 160kDa

Gen-ID: 1828

UniProt: Q02413

Pathways: Cell-Cell Junction Organization