Claudin 6 Antikörper (pTyr219)

Produktnummer ABIN7225802

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Claudin 6 in ELISA, WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für Claudin 6 Antikörper (pTyr219) (ABIN7225802)

Target: Claudin 6 (CLDN6)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 6 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Claudin 6 Antikörper

Bindungsspezifität: pTyr219

Verwendungszweck: Claudin-6 (phospho Tyr219) Polyclonal Antibody

Spezifität: Phospho-Claudin-6 (Y219) Polyclonal Antibody detects endogenous levels of Claudin-6 protein only when phosphorylated at Y219.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Claudin-6 Phospho-Tyr219

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu Claudin 6

Target: Claudin 6 (CLDN6)

Andere Bezeichnung: Claudin-6

Hintergrund: Rabbit Anti-Claudin-6 (phospho Tyr219) Polyclonal Antibody,CLDN6, Claudin-6, Skullin,Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. CLDN6 (claudin 6) encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. CLDN6 methylation may be involved in esophageal tumorigenesis. CLDN6 is adjacent to another family member CLDN9 on chromosome 16.,Claudin-6

Molekulargewicht: observerd band 23kDa

Gen-ID: 9074

UniProt: P56747

Pathways: Hepatitis C