C9orf89 Antikörper (AA 40-120)

Produktnummer ABIN7225394

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch C9orf89 in ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für C9orf89 Antikörper (AA 40-120) (ABIN7225394)

Target: C9orf89 (Chromosome 9 Open Reading Frame 89 (C9orf89))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C9orf89 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-C9orf89 Antikörper

Bindungsspezifität: AA 40-120

Verwendungszweck: Rabbit Anti-BinCARD Polyclonal Antibody

Spezifität: BinCARD Polyclonal Antibody detects endogenous levels of BinCARD protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human BinCARD at AA range: 40-120

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu C9orf89

Target: C9orf89 (Chromosome 9 Open Reading Frame 89 (C9orf89))

Andere Bezeichnung: BinCARD

Hintergrund: C9orf89, Bcl10-interacting CARD protein, BinCARDBinCARD (Bcl10-interacting CARD protein) is a 228 amino acid protein that exists as two alternatively spiced isoforms. BinCARD localizes to nucleus and is expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart, liver, thymus and brain. Containing a CARD domain, BinCARD plays a role in inhibiting the effects of Bcl10-induced activation of NFκB possibly by inhibiting the phosphorylation of Bcl10 in a CARD-dependent manner. The BinCARD gene maps to chromosome 9q22.1. Chromosome 9 consists of about 145 million bases and 4 % of the human genome and encodes nearly 900 genes. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKAP.

Gen-ID: 84270

UniProt: Q96LW7