Caspase 5 p20 Antikörper (Cleaved-Asp121)

Produktnummer ABIN7212444

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Caspase 5 p20 in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Caspase 5 p20 Antikörper (Cleaved-Asp121) (ABIN7212444)

Target: Caspase 5 p20

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 5 p20 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Caspase 5 p20 Antikörper

Bindungsspezifität: AA 80-160, Cleaved-Asp121

Verwendungszweck: Rabbit Anti-Cleaved-Caspase-5 p20 (D121) Polyclonal Antibody

Spezifität: Cleaved-Caspase-5 p20 (D121) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-5 p20 protein resulting from cleavage adjacent to D121.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Caspase-5 p20 at AA range: 80-160

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:20000,Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Caspase 5 p20

Target: Caspase 5 p20

Andere Bezeichnung: Caspase-5 p20

Hintergrund: CASP5, ICH3, Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TYCASP5 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of caspase 5 induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by caspase 5, this process requires Fas-mediated dephosphorylation of Max. The expression of CASP5 is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for CASP5.

Molekulargewicht: 22kD

Gen-ID: 838

UniProt: P51878