CIC Antikörper (AA 550-630)

Produktnummer ABIN7227904

Der Kaninchen Polyklonal anti-CIC Antikörper (ABIN7227904) detektiert spezifisch CIC in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Maus und Human.

Kurzübersicht für CIC Antikörper (AA 550-630) (ABIN7227904)

Target: CIC (Capicua Homolog (CIC))

Reaktivität: Maus, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CIC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CIC Antikörper

Bindungsspezifität: AA 550-630

Verwendungszweck: Rabbit Anti-CIC Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of CIC protein

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human CIC protein at AA range: 550-630

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu CIC

Target: CIC (Capicua Homolog (CIC))

Andere Bezeichnung: CIC

Hintergrund: Protein capicua homologCIC encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID: 6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID: 21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID: 100288687) and FOXO4 (GeneID: 4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 176kD

Gen-ID: 23152

UniProt: Q96RK0