CIC Antikörper (AA 550-630)

Produktnummer ABIN7227904

Dieser Anti-CIC Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von CIC in WB und ELISA. Geeignet für Maus und Human.

Kurzübersicht für CIC Antikörper (AA 550-630) (ABIN7227904)

Target: CIC (Capicua Homolog (CIC))

Reaktivität: Maus, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CIC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CIC Antikörper

Bindungsspezifität: AA 550-630

Verwendungszweck: CIC Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of CIC protein

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human CIC protein at AA range: 550-630

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu CIC

Target: CIC (Capicua Homolog (CIC))

Andere Bezeichnung: CIC

Hintergrund: Rabbit Anti-CIC Polyclonal Antibody,Protein capicua homolog,CIC encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID: 6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID: 21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID: 100288687) and FOXO4 (GeneID: 4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.,CIC

Molekulargewicht: observerd band 176kDa

Gen-ID: 23152

UniProt: Q96RK0