CAGE1 Antikörper (AA 680-760)

Produktnummer ABIN7213916

Der Kaninchen Polyklonal anti-CAGE1 Antikörper wird verwendet zum Nachweis von CAGE1 in Proben von Human, Maus und Ratte. Er wurde validiert für ELISA, WB, IHC und IF.

Kurzübersicht für CAGE1 Antikörper (AA 680-760) (ABIN7213916)

Target: CAGE1 (Cancer Antigen 1 (CAGE1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAGE1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-CAGE1 Antikörper

Bindungsspezifität: AA 680-760

Verwendungszweck: Rabbit Anti-CAGE-1 Polyclonal Antibody

Spezifität: CAGE-1 Polyclonal Antibody detects endogenous levels of CAGE-1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human CAGE-1 at AA range: 680-760

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu CAGE1

Target: CAGE1 (Cancer Antigen 1 (CAGE1))

Andere Bezeichnung: CAGE-1

Hintergrund: CAGE1, CTAG3, Cancer-associated gene 1 protein, CAGE-1, Cancer/testis antigen 3, CT3CAGE (cancer-associated gene protein), also known as DEAD box protien 53 (DDX53) or DEAD box protein CAGE, belongs to the DEAD box helicase family. It contains one helicase ATP-binding domain, one helicase C-terminal domain and one KH domain. CAGE localizes to the nucleus and, in normal adult tissues, is exclusively expressed in testis but it has also been found in a wide variety of cancer tissues and cell lines. Overexpression of CAGE leads to the activation of FAK, ERK and p38 MAPK along with a reduction in reactive oxygen species (ROS). It is also responsible for inducing catalase activity and therefore enhancing cell motility. This suggests that CAGE may enhance the migration of cancer cells. In addition, hypomethylation of the CAGE promoter region is associated with tumor progression and may serve as a valuable marker in cancer diagnosis.

Molekulargewicht: 90kD

Gen-ID: 285782

UniProt: Q8TC20