AGRN Antikörper (AA 1900-1980)

Produktnummer ABIN7227240

Der Kaninchen Polyklonal anti-AGRN Antikörper wird verwendet zum Nachweis von AGRN in Proben von Human, Ratte und Maus. Er wurde validiert für WB und ELISA.

Kurzübersicht für AGRN Antikörper (AA 1900-1980) (ABIN7227240)

Target: AGRN (Agrin (AGRN))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AGRN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-AGRN Antikörper

Bindungsspezifität: AA 1900-1980

Verwendungszweck: Rabbit Anti-AGRIN Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of AGRIN protein

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human AGRIN protein at AA range: 1900-1980

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu AGRN

Target: AGRN (Agrin (AGRN))

Andere Bezeichnung: AGRIN

Hintergrund: Agrin, Agrin N-terminal 110 kDa subunit, Agrin C-terminal 110 kDa subunit, Agrin C-terminal 90 kDa fragment, C90, Agrin C-terminal 22 kDa fragment, C22AGRN encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in AGRN was found. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 224kD

Gen-ID: 375790

UniProt: O00468

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development