ABL1/2 Antikörper

Produktnummer ABIN7213438

Der Kaninchen Polyklonal anti-ABL1/2 Antikörper wird verwendet zum Nachweis von ABL1/2 in Proben von Human und Maus. Er wurde validiert für IHC, WB, IF und ELISA.

Kurzübersicht für ABL1/2 Antikörper (ABIN7213438)

Target: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABL1/2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), ELISA

Produktdetails anti-ABL1/2 Antikörper

Verwendungszweck: Rabbit Anti-Abl1/2 Polyclonal Antibody

Spezifität: Abl1/2 Polyclonal Antibody detects endogenous levels of Abl1/2 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Abl1/2 around the non-phosphorylation site of Y393/439

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu ABL1/2

Target: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Andere Bezeichnung: Abl1/2

Hintergrund: ABL1, ABL, JTK7, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL2, ABLL, ARG, Abelson tyrosine-protein kinase 2, Abelson murine leukemia viraABL1 is a protooncogene that encodes a protein tyrosine kinase (ABL proto-oncogene 1, non-receptor tyrosine kinase) involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. ABL1 has been found fused to a variety of translocation partner genes in various leukemias, most notably the t (9,22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR, MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Molekulargewicht: 125kD

Gen-ID: 25, 27

UniProt: P00519, P42684