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SRGAP1 Antikörper

SRGAP1 Reaktivität: Human ELISA, WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7192644
  • Target Alle SRGAP1 Antikörper anzeigen
    SRGAP1 (SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1))
    Reaktivität
    • 37
    • 17
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 32
    • 5
    Kaninchen
    Klonalität
    • 34
    • 3
    Polyklonal
    Konjugat
    • 16
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SRGAP1 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 20
    • 5
    • 4
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    Antigen affinity purification
    Immunogen
    Synthetic peptide of Human SRGAP1
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SRGAP1 (SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1))
    Andere Bezeichnung
    SRGAP1 (SRGAP1 Produkte)
    Synonyme
    ARHGAP13 antikoerper, 4930572H05Rik antikoerper, Arhgap13 antikoerper, RGD1566260 antikoerper, SLIT-ROBO Rho GTPase activating protein 1 antikoerper, SRGAP1 antikoerper, srgap1 antikoerper, Srgap1 antikoerper
    Hintergrund

    Background: SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 µLtimately leads to a decrease in actin polymerization.

    Aliases: 4930572H05Rik antibody, ARHGAP13 antibody, FLJ22166 antibody, KIAA1304 antibody, RGD1566260 antibody, Rho GTPase activating protein 13 antibody, Rho GTPase-activating protein 13 antibody, SLIT ROBO Rho GTPase activating protein 1 antibody, SLIT-ROBO Rho GTPase-activating protein 1 antibody, SRGAP 1 antibody, srGAP1 antibody, SRGP1_HUMAN antibody

    UniProt
    Q7Z6B7
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