SRGAP1 Antikörper

Produktnummer ABIN7192644

Dieser Anti-SRGAP1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von SRGAP1 in ELISA, WB und IHC. Geeignet für Human.

Kurzübersicht für SRGAP1 Antikörper (ABIN7192644)

Target: SRGAP1 (SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRGAP1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SRGAP1 Antikörper

Verwendungszweck: SRGAP1 Antibody

Kreuzreaktivität: Maus

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of Human SRGAP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:  pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SRGAP1

Target: SRGAP1 (SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1))

Andere Bezeichnung: SRGAP1

Hintergrund:

Background: SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 µLtimately leads to a decrease in actin polymerization.

Aliases: 4930572H05Rik antibody, ARHGAP13 antibody, FLJ22166 antibody, KIAA1304 antibody, RGD1566260 antibody, Rho GTPase activating protein 13 antibody, Rho GTPase-activating protein 13 antibody, SLIT ROBO Rho GTPase activating protein 1 antibody, SLIT-ROBO Rho GTPase-activating protein 1 antibody, SRGAP 1 antibody, srGAP1 antibody, SRGP1_HUMAN antibody

UniProt: Q7Z6B7