CHRDL2 Antikörper

Produktnummer ABIN7190246

Der Kaninchen Polyklonal Anti-CHRDL2-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, CHRDL2 in Proben von Human zu detektieren.

Kurzübersicht für CHRDL2 Antikörper (ABIN7190246)

Target: CHRDL2 (Chordin-Like 2 (CHRDL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHRDL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-CHRDL2 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of Human CHRDL2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CHRDL2

Target: CHRDL2 (Chordin-Like 2 (CHRDL2))

Andere Bezeichnung: CHRDL2

Hintergrund:

Background: CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.

Aliases: BNF-1 antibody, BNF1 antibody, Breast tumor novel factor 1 antibody, CHL2 antibody, chordin like 2 antibody, Chordin like protein 2 precursor antibody, Chordin related protein 2 antibody, Chordin-like protein 2 antibody, Chordin-related protein 2 antibody, Chrdl2 antibody, CRDL2_HUMAN antibody, DKFZp586N2124 antibody, FKSG37 antibody

UniProt: Q6WN34